John Myers was the son of a white man A.G. Myers and an African Creek woman, Harriett Cosmay who was a Creek Freedwoman. As a young man, John Myers served as the personal interpreter to the Creek leader Isparhecher, during the time of the Green Peach War. During that time of conflict, Myers accompanied Isparhechar into Comanche country, when he took refuge there. He returned with Isparhechar back to the Creek Nation under escort of U.S. soldiers.
John Myers spent later years as a Creek Lighthorseman, serving 8 years in that capacity. John Myers married Hagar Lewis, also a Creek Freedwoman, and they raised 4 children. His children attended the Tullahasse Mission School for Creek Freedmen.
He spent his remaining years in the Muskogee area.